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adam17 proteolytic activities  (BPS Bioscience)


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    BPS Bioscience adam17 proteolytic activities
    Adam17 Proteolytic Activities, supplied by BPS Bioscience, used in various techniques. Bioz Stars score: 94/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/adam17+proteolytic+activities/ADAM17+Fluorogenic+Assay+Kit/pm41337883-160-2-18
    Average 94 stars, based on 6 article reviews
    adam17 proteolytic activities - by Bioz Stars, 2026-09
    94/100 stars

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    Related Articles

    Western Blot:

    Article Title: As48, a first-in-class dual-function TREM2 modulator: Receptor activation and shedding inhibition.
    Article Snippet: ADAM10 and ADAM17 proteolytic activities were measured using ADAM10 Fluorogenic Assay Kit and ADAM17 Fluorogenic Assay Kit, respectively (BPS Bioscience, San Diego, CA, USA). .. A

    Article Title: As48, a First-in-Class Dual-Function TREM2 Modulator: Receptor Activation and Shedding Inhibition
    Article Snippet: ADAM10 and ADAM17 proteolytic activities were measured using ADAM10 Fluorogenic Assay Kit and ADAM17 Fluorogenic Assay Kit, respectively (BPS Bioscience, San Diego, CA, USA). .. A

    Positive Control:

    Article Title: As48, a first-in-class dual-function TREM2 modulator: Receptor activation and shedding inhibition.
    Article Snippet: ADAM10 and ADAM17 proteolytic activities were measured using ADAM10 Fluorogenic Assay Kit and ADAM17 Fluorogenic Assay Kit, respectively (BPS Bioscience, San Diego, CA, USA). .. A

    Article Title: As48, a First-in-Class Dual-Function TREM2 Modulator: Receptor Activation and Shedding Inhibition
    Article Snippet: ADAM10 and ADAM17 proteolytic activities were measured using ADAM10 Fluorogenic Assay Kit and ADAM17 Fluorogenic Assay Kit, respectively (BPS Bioscience, San Diego, CA, USA). .. A

    Inhibition:

    Article Title: As48, a first-in-class dual-function TREM2 modulator: Receptor activation and shedding inhibition.
    Article Snippet: ADAM10 and ADAM17 proteolytic activities were measured using ADAM10 Fluorogenic Assay Kit and ADAM17 Fluorogenic Assay Kit, respectively (BPS Bioscience, San Diego, CA, USA). .. A

    Article Title: As48, a First-in-Class Dual-Function TREM2 Modulator: Receptor Activation and Shedding Inhibition
    Article Snippet: ADAM10 and ADAM17 proteolytic activities were measured using ADAM10 Fluorogenic Assay Kit and ADAM17 Fluorogenic Assay Kit, respectively (BPS Bioscience, San Diego, CA, USA). .. A

    Two Tailed Test:

    Article Title: As48, a first-in-class dual-function TREM2 modulator: Receptor activation and shedding inhibition.
    Article Snippet: ADAM10 and ADAM17 proteolytic activities were measured using ADAM10 Fluorogenic Assay Kit and ADAM17 Fluorogenic Assay Kit, respectively (BPS Bioscience, San Diego, CA, USA). .. A

    Article Title: As48, a First-in-Class Dual-Function TREM2 Modulator: Receptor Activation and Shedding Inhibition
    Article Snippet: ADAM10 and ADAM17 proteolytic activities were measured using ADAM10 Fluorogenic Assay Kit and ADAM17 Fluorogenic Assay Kit, respectively (BPS Bioscience, San Diego, CA, USA). .. A



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    adam17 proteolytic activities  (BPS Bioscience)
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    θ-Defensins inhibit TACE and suppress TNF release by LPS-stimulated THP-1 monocytes. A and C, inhibition of recombinant TACE <t>proteolytic</t> activity is shown as percent change in rate of product formation relative to peptide-free control. Enzyme reactions were performed for 30 min at 22 °C with 2 nm TACE and 10 μm substrate (R&D Systems, ES003). Data represent mean ± S.E. of 3 independent experiments containing 2–3 technical repeats each. B and D, suppression of TNF release from THP-1 monocytes stimulated with LPS and peptides or marimastat (MRM). Results are expressed as mean ± S.D. of 2- 6 individual experiments containing 2 technical repeats each.
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    adam10 inhibition assays proteolytic activities  (R&D Systems)
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    RTDs inhibit cellular TACE and <t>ADAM10</t> sheddase activities. A and B, RTDs, but not acyclic S7 or α-defensin HNP-4, suppress TACE-mediated ectodomain shedding of TGFα in COS7 cells. Data are expressed as fold-TGFα shedding relative to constitutive TGFα release. C, RTD-1, but not S7 or HNP-4, inhibits ADAM10-dependent cleavage of BTC in COS7 cells. Data are expressed as fold BTC shedding relative to constitutive BTC release. Data in panels A--C represent mean ± S.D. of a representative experiment containing 3 technical repeats. D, RTDs inhibit rADAM10 proteolysis of its fluorogenic substrate. Enzyme reactions were performed for 30 min at 37 °C with 1 nm ADAM10 and 10 μm substrate (R&D Systems, ES010). Enzyme inhibition is expressed as percent change in substrate conversion rate relative to peptide-free controls. Data represent mean ± S.D. of 2 independent experiments containing 2 technical repeats each.
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    θ-Defensins inhibit TACE and suppress TNF release by LPS-stimulated THP-1 monocytes. A and C, inhibition of recombinant TACE proteolytic activity is shown as percent change in rate of product formation relative to peptide-free control. Enzyme reactions were performed for 30 min at 22 °C with 2 nm TACE and 10 μm substrate (R&D Systems, ES003). Data represent mean ± S.E. of 3 independent experiments containing 2–3 technical repeats each. B and D, suppression of TNF release from THP-1 monocytes stimulated with LPS and peptides or marimastat (MRM). Results are expressed as mean ± S.D. of 2- 6 individual experiments containing 2 technical repeats each.

    Journal: The Journal of Biological Chemistry

    Article Title: Macrocyclic θ-defensins suppress tumor necrosis factor-α (TNF-α) shedding by inhibition of TNF-α–converting enzyme

    doi: 10.1074/jbc.RA117.000793

    Figure Lengend Snippet: θ-Defensins inhibit TACE and suppress TNF release by LPS-stimulated THP-1 monocytes. A and C, inhibition of recombinant TACE proteolytic activity is shown as percent change in rate of product formation relative to peptide-free control. Enzyme reactions were performed for 30 min at 22 °C with 2 nm TACE and 10 μm substrate (R&D Systems, ES003). Data represent mean ± S.E. of 3 independent experiments containing 2–3 technical repeats each. B and D, suppression of TNF release from THP-1 monocytes stimulated with LPS and peptides or marimastat (MRM). Results are expressed as mean ± S.D. of 2- 6 individual experiments containing 2 technical repeats each.

    Article Snippet: Proteolytic activities of recombinant human TACE (R&D Systems, 930-ADB, 52 kDa, full ectodomain) and ADAM10 (R&D Systems, 936-AD, 52 kDa, full ectodomain) were measured using fluorogenic substrates Mca-PLAQAV-Dpa-RSSSR-NH 2 (R&D Systems, ES003) and Mca-KPLGL-Dpa-AR-NH 2 (R&D Systems, ES010), respectively.

    Techniques: Inhibition, Recombinant, Activity Assay, Control

    RTDs inhibit cellular TACE and ADAM10 sheddase activities. A and B, RTDs, but not acyclic S7 or α-defensin HNP-4, suppress TACE-mediated ectodomain shedding of TGFα in COS7 cells. Data are expressed as fold-TGFα shedding relative to constitutive TGFα release. C, RTD-1, but not S7 or HNP-4, inhibits ADAM10-dependent cleavage of BTC in COS7 cells. Data are expressed as fold BTC shedding relative to constitutive BTC release. Data in panels A--C represent mean ± S.D. of a representative experiment containing 3 technical repeats. D, RTDs inhibit rADAM10 proteolysis of its fluorogenic substrate. Enzyme reactions were performed for 30 min at 37 °C with 1 nm ADAM10 and 10 μm substrate (R&D Systems, ES010). Enzyme inhibition is expressed as percent change in substrate conversion rate relative to peptide-free controls. Data represent mean ± S.D. of 2 independent experiments containing 2 technical repeats each.

    Journal: The Journal of Biological Chemistry

    Article Title: Macrocyclic θ-defensins suppress tumor necrosis factor-α (TNF-α) shedding by inhibition of TNF-α–converting enzyme

    doi: 10.1074/jbc.RA117.000793

    Figure Lengend Snippet: RTDs inhibit cellular TACE and ADAM10 sheddase activities. A and B, RTDs, but not acyclic S7 or α-defensin HNP-4, suppress TACE-mediated ectodomain shedding of TGFα in COS7 cells. Data are expressed as fold-TGFα shedding relative to constitutive TGFα release. C, RTD-1, but not S7 or HNP-4, inhibits ADAM10-dependent cleavage of BTC in COS7 cells. Data are expressed as fold BTC shedding relative to constitutive BTC release. Data in panels A--C represent mean ± S.D. of a representative experiment containing 3 technical repeats. D, RTDs inhibit rADAM10 proteolysis of its fluorogenic substrate. Enzyme reactions were performed for 30 min at 37 °C with 1 nm ADAM10 and 10 μm substrate (R&D Systems, ES010). Enzyme inhibition is expressed as percent change in substrate conversion rate relative to peptide-free controls. Data represent mean ± S.D. of 2 independent experiments containing 2 technical repeats each.

    Article Snippet: TACE and ADAM10 inhibition assays Proteolytic activities of recombinant human TACE (R&D Systems, 930-ADB, 52 kDa, full ectodomain) and ADAM10 (R&D Systems, 936-AD, 52 kDa, full ectodomain) were measured using fluorogenic substrates Mca-PLAQAV-Dpa-RSSSR-NH 2 (R&D Systems, ES003) and Mca-KPLGL-Dpa-AR-NH 2 (R&D Systems, ES010), respectively.

    Techniques: Enzyme Inhibition Assay